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Introduction
Function
Figure 1. DPPIV structure
DPPIV, a moonlighting protein, has been implicated in many functions and diseases of the body including glucose metabolism, cardiovascular disease, the stress response, autoimmune diseases (ie HIV/AIDS), inflammation, and tumor biology.
Catalytic Triad
The Catalytic Triad of DPP4 is Ser630, His740, Asp708.
Mechanism
Figure 2. DPPIV Mechanism
The mechanism for the truncation of GLP-1 using DPP4 is a covalent catalysis. 708
1st Nucleophile is Oxygen on Ser630 and the 2nd Nucleophile is water.
Disease
Relevance
Structural highlights
sheets and light sky blue and helices are light green
"cystine rich region" 351-506
Caveolin-1 binding site (ADA) 201-210 and See 630
________
catalytic domain (green)
beta-propeller (red)
cytosine rich (yellow)
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
