Function
Melanoma-associated antigen (MAGE) are produced by tumor cells and are recognized by cytotoxic T lymphocytes[1]. Many such antigens have been identified and are classified into 2 groups with group I called cancer/testis antigens[2]. The loss of MAGE expression is observed in primary melanoma[3].
Disease
Relevance
The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer[4]. Assessment of MAGE may provide stratification factor for active-specific immunotherapy[5].
Structural highlights
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3D structures of melanoma-associated antigen
Updated on 16-April-2024
MAGE; Domains: MAGE homology 101-317; PWWP 405-538
3pmi – hMAGE1 PWWP domain (mutant) – human
4v0p – hMAGEA3 MAGE homology domain
8t9a – hMAGEA3 MAGE homology domain + DDB1-DCAF12 – Cryo EM
2wa0 – hMAGEA4 MAGE homology domain
7uoa – hMAGEA4 MAGE homology domain + peptide inhibitor
6r7t – hMAGEB1 MAGE homology domain + nanobody
5hvq, 5wy5 – hMAGEG1 MAGE homology domain + NSE-1
6xr0 – hMAGEP97 + antibody
