Function
Sodium/glucose cotransporter (SGLT) is responsible for glucose absorption across membranes. SGLT1 and SGLT2 which are expressed in different tissues, have similar active sites but differ in their non-active site structures. SGLT1 is responsible of glucose absorption in the small intestine and SGLT2 in kidney[1].
Disease
Mutations in SGLT1 cause malabsorption of glucose and galactose[2].
Relevance
SGLT2 inhibitors aid in hypertension, acute cardiac failure, bradycardia, acute pulmonary oedema, asthma, bronchitis and COPD[3].
Structural highlights
The drug dapaglifozin contains a glucose moiety which stacks against residue Y290 of SGLT2. The glucose moiety forms multiple H-bonds to SGLT2[4].
3D structures of sodium/glucose cotransporter
Sodium/glucose cotransporter 3D structures
