Structural highlights
Function
CARR_PSEAE Member of the two-component regulatory system CarS/CarR that regulates the expression of multiple genes involved in calcium signaling and homeostasis including CarO and CarP (PubMed:26755627, PubMed:33674436). May function as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target gene promoters (PubMed:26755627).[1] [2]
References
- ↑ Guragain M, King MM, Williamson KS, Pérez-Osorio AC, Akiyama T, Khanam S, Patrauchan MA, Franklin MJ. The Pseudomonas aeruginosa PAO1 Two-Component Regulator CarSR Regulates Calcium Homeostasis and Calcium-Induced Virulence Factor Production through Its Regulatory Targets CarO and CarP. J Bacteriol. 2016 Jan 11;198(6):951-63. PMID:26755627 doi:10.1128/JB.00963-15
- ↑ King M, Kubo A, Kafer L, Braga R, McLeod D, Khanam S, Conway T, Patrauchan MA. Calcium-Regulated Protein CarP Responds to Multiple Host Signals and Mediates Regulation of Pseudomonas aeruginosa Virulence by Calcium. Appl Environ Microbiol. 2021 Apr 27;87(10):e00061-21. PMID:33674436 doi:10.1128/AEM.00061-21
