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spinqualitylabelsall models 1u8c, resolution 3.1Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

A novel adaptation of the integrin PSI domain revealed from its crystal structure

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Integrin beta-subunits contain an N-terminal PSI (for, plexin-semaphorin-integrin) domain that contributes to integrin activation, and harbors the PI(A) alloantigen associated with immune thrombocytopenias, and susceptibility to sudden cardiac death. Here we report the crystal, structure of PSI in the context of the crystallized alphaVbeta3, ectodomain. The integrin PSI forms a two-stranded antiparallel beta-sheet, flanked by two short helices; its long interstrand loop houses Pl(A) and, may face the EGF2 domain. The integrin PSI contains four cysteine pairs, connected in a 1-4, 2-8, 3-6, 5-7 pattern. An unexpected feature of the, structure is that the final, eighth cysteine is located C-terminal to the, Ig-like hybrid domain and is thus separated by the hybrid domain from the, other seven cysteines of PSI. This architecture may be relevant to the, evolution of integrins and should help refine the current models of, integrin activation.

Disease

Known diseases associated with this structure: Glanzmann thrombasthenia, type B OMIM:[173470]

About this Structure

1U8C is a Protein complex structure of sequences from Homo sapiens with NAG, NDG and CA as ligands. Full crystallographic information is available from OCA.

Reference

A novel adaptation of the integrin PSI domain revealed from its crystal structure., Xiong JP, Stehle T, Goodman SL, Arnaout MA, J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6. PMID:15299032

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