Function
Integrator complex (Int) is a protein complex which induces termination at loci transcribed by RNA polymerase II. Multiple Int subunits coordinate effective termination[1]. Int consists of 14 subunits some of which act as RNA endonuclease and are essential for small nuclear RNA biogenesis[2]
Disease
Mutations in Int subunit 1 and 8 are associated with rare recessive neurodevelopmental syndromes[3]
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
