1u9w

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spinqualitylabelsall models 1u9w, resolution 2.3Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Starting from the high-throughput screening hit 1a, novel cathepsin K, inhibitors have been developed based on a purine scaffold. High-resolution, X-ray structures of several derivatives have revealed the binding mode of, these unique cysteine protease inhibitors.

Disease

Known disease associated with this structure: Pycnodysostosis OMIM:[601105]

About this Structure

1U9W is a Single protein structure of sequence from Homo sapiens with IHI as ligand. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.

Reference

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K., Altmann E, Cowan-Jacob SW, Missbach M, J Med Chem. 2004 Nov 18;47(24):5833-6. PMID:15537340

Page seeded by OCA on Mon Nov 12 19:32:51 2007