8r8q

Structural highlights

Function

MFSD1_MOUSE Lysosomal transporter which is essential for liver homeostasis (PubMed:31661432). Required to maintain stability and lysosomal localization of GLMP (PubMed:31661432, PubMed:32959924).^{[1] [2]}

References

1. ↑ Massa López D, Thelen M, Stahl F, Thiel C, Linhorst A, Sylvester M, Hermanns-Borgmeyer I, Lüllmann-Rauch R, Eskild W, Saftig P, Damme M. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. Elife. 2019 Oct 29;8:e50025. PMID:31661432 doi:10.7554/eLife.50025
2. ↑ López DM, Kählau L, Jungnickel KEJ, Löw C, Damme M. Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP. FASEB J. 2020 Nov;34(11):14695-14709. PMID:32959924 doi:10.1096/fj.202000912RR