Structural highlights
Disease
RFX5_HUMAN Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.
Function
RFX5_HUMAN Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
