2kxj

Structural highlights

Function

UBXN4_HUMAN Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).^{[1] [2]}

References

1. ↑ Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon RA, Monteiro MJ. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J Cell Sci. 2006 Oct 1;119(Pt 19):4011-24. Epub 2006 Sep 12. PMID:16968747 doi:http://dx.doi.org/jcs.03163
2. ↑ Lim PJ, Danner R, Liang J, Doong H, Harman C, Srinivasan D, Rothenberg C, Wang H, Ye Y, Fang S, Monteiro MJ. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol. 2009 Oct 19;187(2):201-17. Epub 2009 Oct 12. PMID:19822669 doi:http://dx.doi.org/jcb.200903024