2l5r

Structural highlights

Function

ATI1C_ALYOB Antibacterial peptide with amphipathic alpha-helical structure that shows selective growth-inhibitory activity against Gram-negative bacteria but low hemolytic activity against human erythrocytes (LC(50)=145-220 uM) (PubMed:19463738, PubMed:21565166). It is moderately active against the Gram-negative bacteria E.coli (MIC=25 uM), K.pneumoniae (MIC=50 uM), P.aeruginosa (MIC=25 uM), A.baumannii (MIC=6 uM), and is weaky active against the Gram-positive S.aureus (MIC=100-250 uM) (PubMed:19463738, PubMed:21565166).^{[1] [2]}

References

1. ↑ Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC. The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). Peptides. 2009 Jun;30(6):1069-73. PMID:19463738 doi:10.1016/j.peptides.2009.03.004
2. ↑ Subasinghage AP, O'Flynn D, Conlon JM, Hewage CM. Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c. Biochim Biophys Acta. 2011 Aug;1808(8):1975-84. Epub 2011 Apr 30. PMID:21565166 doi:10.1016/j.bbamem.2011.04.012