7agv

Structural highlights

Function

KHTT_BACSU Required for activity of the potassium/proton antiporter KhtU (PubMed:14987767, PubMed:17679694). Involved in protection of the cell from methylglyoxal, a toxic by-product of glycolysis (PubMed:24330391).^{[1] [2] [3]}

References

1. ↑ Fujisawa M, Wada Y, Ito M. Modulation of the K+ efflux activity of Bacillus subtilis YhaU by YhaT and the C-terminal region of YhaS. FEMS Microbiol Lett. 2004 Feb 16;231(2):211-7. doi:, 10.1016/S0378-1097(03)00959-5. PMID:14987767 doi:http://dx.doi.org/10.1016/S0378-1097(03)00959-5
2. ↑ Fujisawa M, Ito M, Krulwich TA. Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13289-94. doi:, 10.1073/pnas.0703709104. Epub 2007 Aug 6. PMID:17679694 doi:http://dx.doi.org/10.1073/pnas.0703709104
3. ↑ Chandrangsu P, Dusi R, Hamilton CJ, Helmann JD. Methylglyoxal resistance in Bacillus subtilis: contributions of bacillithiol-dependent and independent pathways. Mol Microbiol. 2014 Feb;91(4):706-15. doi: 10.1111/mmi.12489. Epub 2014 Jan 7. PMID:24330391 doi:http://dx.doi.org/10.1111/mmi.12489