1ujl

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Solution Structure of the HERG K+ channel S5-P extracellular linker

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The HERG K+ channel has very unusual kinetic behaviour that includes slow, activation but rapid inactivation. These features are critical for normal, cardiac repolarisation as well as in preventing lethal ventricular, arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed, identification of which regions of the channel are important for the, unusual kinetic behaviour of the channel. Furthermore, structural studies, on scorpion toxins that potently inhibit HERG are beginning to provide, clues as to the structural differences between HERG and other, voltage-gated K+ channels.

Disease

Known diseases associated with this structure: Lathosterolosis OMIM:[602286], Long QT syndrome, acquired, susceptibility to OMIM:[152427], Long QT syndrome-2 OMIM:[152427], Short QT syndrome-1 OMIM:[152427]

About this Structure

1UJL is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209

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