2v7r

Publication Abstract from PubMed

The tRNA(Gly)/glycyl-tRNA synthetase (GlyRS) system belongs to the so-called 'class II aminoacyl-tRNA synthetase system' in which tRNA identity elements are assured by rather few and simple determinants mostly located in the tRNA acceptor stem. Regarding evolutionary aspects, the tRNA(Gly)/GlyRS system is a special case. There exist two different types of GlyRS, namely an archaebacterial/human type and a eubacterial type reflecting an evolutionary divergence within this system. Here we report the crystal structure of a human tRNA(Gly) acceptor stem microhelix at 1.2A resolution. The local geometric parameters of the microhelix and the water network surrounding the RNA are presented. The structure complements the previously published Escherichia coli tRNA(Gly) aminoacyl stem structure.

Crystal structure of a human tRNA(Gly) microhelix at 1.2A resolution.,Forster C, Mankowska M, Furste JP, Perbandt M, Betzel Ch, Erdmann VA Biochem Biophys Res Commun. 2008 Apr 18;368(4):996-1001. Epub 2008 Feb 13. PMID:18279665^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.