1urn
From Proteopedia
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U1A MUTANT/RNA COMPLEX + GLYCEROL
Overview
The crystal structure of the RNA-binding domain of the small nuclear, ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been, determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the, surface of the beta-sheet as an open structure, and the AUUGCAC sequence, of the loop interacts extensively with the conserved RNP1 and RNP2 motifs, and the C-terminal extension of the RNP domain. These interactions include, stacking of RNA bases with aromatic side chains of proteins and many, direct and water-mediated hydrogen bonds. The structure reveals the, stereochemical basis for sequence-specific RNA recognition by the RNP, domain.
About this Structure
1URN is a Single protein structure of sequence from Homo sapiens with CL and GOL as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237
Page seeded by OCA on Mon Nov 12 19:37:56 2007
Categories: Homo sapiens | Single protein | Evans, P.R. | Ito, N. | Nagai, K. | Oubridge, C. | Teo, C.H. | CL | GOL | Hairpin loop | Overhanging base | Protein-rna complex | Single strand
