1x61

Structural highlights

Function

TRIP6_HUMAN Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.^{[1] [2] [3] [4]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Kassel O, Schneider S, Heilbock C, Litfin M, Gottlicher M, Herrlich P. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. Genes Dev. 2004 Oct 15;18(20):2518-28. PMID:15489293 doi:http://dx.doi.org/10.1101/gad.322404
2. ↑ Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12;279(11):10459-68. Epub 2003 Dec 18. PMID:14688263 doi:http://dx.doi.org/10.1074/jbc.M311891200
3. ↑ Solaz-Fuster MC, Gimeno-Alcaniz JV, Casado M, Sanz P. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cell Signal. 2006 Oct;18(10):1702-12. Epub 2006 Mar 6. PMID:16624523 doi:http://dx.doi.org/10.1016/j.cellsig.2006.01.021
4. ↑ Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets L. TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J. 2009 Mar;23(3):916-28. doi: 10.1096/fj.08-106344. Epub 2008 Nov 18. PMID:19017743 doi:http://dx.doi.org/10.1096/fj.08-106344