Structural highlights
Function
KDM5_DROME Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.[1] [2] [3] [4]
References
- ↑ Gildea JJ, Lopez R, Shearn A. A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics. 2000 Oct;156(2):645-63. PMID:11014813
- ↑ Secombe J, Li L, Carlos L, Eisenman RN. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 2007 Mar 1;21(5):537-51. Epub 2007 Feb 20. PMID:17311883 doi:http://dx.doi.org/10.1101/gad.1523007
- ↑ Lee N, Zhang J, Klose RJ, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol. 2007 Apr;14(4):341-3. Epub 2007 Mar 11. PMID:17351631 doi:http://dx.doi.org/10.1038/nsmb1216
- ↑ Eissenberg JC, Lee MG, Schneider J, Ilvarsonn A, Shiekhattar R, Shilatifard A. The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol. 2007 Apr;14(4):344-6. Epub 2007 Mar 11. PMID:17351630 doi:http://dx.doi.org/10.1038/nsmb1217
