2dam

Structural highlights

Function

FAF2_HUMAN Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460).^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Mueller B, Klemm EJ, Spooner E, Claessen JH, Ploegh HL. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12325-30. doi:, 10.1073/pnas.0805371105. Epub 2008 Aug 18. PMID:18711132 doi:http://dx.doi.org/10.1073/pnas.0805371105
2. ↑ Xia Y, Yan LH, Huang B, Liu M, Liu X, Huang C. Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation. J Neurochem. 2014 Apr;129(1):99-106. doi: 10.1111/jnc.12606. Epub 2013 Nov 22. PMID:24215460 doi:http://dx.doi.org/10.1111/jnc.12606