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spinqualitylabelsall models 1vsc, resolution 1.9Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

VCAM-1

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and, functionally distinct class of immunoglobulin superfamily molecules that, bind leukocyte integrins and are involved in inflammatory and immune, functions. X-ray crystallography defines the three-dimensional structure, of the N-terminal two-domain fragment that participates in ligand binding., Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact, between domains 1 and 2. A cyclic peptide that mimics this loop inhibits, binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data, demonstrate how crystallographic structural information can be used to, design a small molecule inhibitor of biological function.

Disease

Known diseases associated with this structure: CRASH syndrome OMIM:[308840], Corpus callosum, partial agenesis of OMIM:[308840], Hydrocephalus due to aqueductal stenosis OMIM:[308840], Hydrocephalus with Hirschsprung disease and cleft palate OMIM:[308840], Hydrocephalus with congenital idiopathic intestinal pseudoobstruction OMIM:[308840], MASA syndrome OMIM:[308840]

About this Structure

1VSC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction., Wang JH, Pepinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L, Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5714-8. PMID:7539925

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