Structural highlights
Function
NOSTN_HUMAN Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17167-72. Epub 2002 Nov 21. PMID:12446846 doi:http://dx.doi.org/10.1073/pnas.252345399
- ↑ Icking A, Matt S, Opitz N, Wiesenthal A, Muller-Esterl W, Schilling K. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci. 2005 Nov 1;118(Pt 21):5059-69. Epub 2005 Oct 18. PMID:16234328 doi:http://dx.doi.org/jcs.02620
- ↑ Schilling K, Opitz N, Wiesenthal A, Oess S, Tikkanen R, Muller-Esterl W, Icking A. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell. 2006 Sep;17(9):3870-80. Epub 2006 Jun 28. PMID:16807357 doi:http://dx.doi.org/E05-08-0709
