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spinqualitylabelsall models Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry 2qja) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 Disease 4 3D structures of bone morphogenetic protein Function Bone morphogenetic protein (BMP) are growth factors which can induce formation of bone and cartllage'[1]. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. BMP-1 cleaves the C-propeptides of type I pro collagen during the synthesis of extracellular collagen fibrils[2]. For details on BMP-7 see Student Projects for UMass Chemistry 423 Spring 2012-4. See also Growth factors, Enzyme-linked receptor Growth differentiation factor TGF beta signaling pathway. Relevance Recombinant BMP is used in oral surgery and spinal fusion. Disease BMP-7 is involved in chronic kidney disease[3]. 3D structures of bone morphogenetic protein Bone morphogenetic protein 3D structures

References

1. ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
2. ↑ Hartigan N, Garrigue-Antar L, Kadler KE. Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. J Biol Chem. 2003 May 16;278(20):18045-9. PMID:12637537 doi:10.1074/jbc.M211448200
3. ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541