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The SPPV14
The elimination of infected cells through programmed cell death (apoptosis) is the most common response against infectious agents, acting as a primary defense mechanism. In order to prevail in face of such mechanisms, several viruses express inhibitors that prevent apoptosis, combating the host's innate defenses. Sheeppox virus expresses SPPV14, an inhibitor that intervenes in the pro- or anti-apoptotic pathways mediated by the Bcl-2 protein family, exhibiting a high inhibitory capacity for apoptosis in virus-infected cells. Unlike most viral strategies, which target the production of Bcl-2 homologs (anti-apoptotic)[1], SPPV14 is a potent inhibitor of Hrk, Bax and Bak (pro-apoptotic)[2]. This protein shares high similarity with DPV022 (deerpox), which is structurally the closest to SPPV14.
Function
Disease
Relevance
Structural highlights
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