8wo8

Structural highlights

Function

FAU1_PYRFU Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA (PubMed:28978920). Binds to RNA in loop regions with AU-rich sequences. Binds to the consensus sequence GGC(U/A)(U/A)U(U/C) in vitro (PubMed:12614195).^{[1] [2]}

References

1. ↑ Kanai A, Oida H, Matsuura N, Doi H. Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus. Biochem J. 2003 May 15;372(Pt 1):253-61. PMID:12614195 doi:10.1042/BJ20021968
2. ↑ Ikeda Y, Okada Y, Sato A, Kanai T, Tomita M, Atomi H, Kanai A. An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus. Sci Rep. 2017 Oct 4;7(1):12674. PMID:28978920 doi:10.1038/s41598-017-13062-3