Ferric hydroxamate uptake receptor

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spinqualitylabelsall models E. coli FhuA complex with ferrichrome and Fe+3 ion (orange) (PDB code 1by5). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Ferric hydroxamate uptake receptor or ferrichrome-binding periplasmic protein proteins FhuA, FhuB, FhuC and FhuD are involved in the uptake of the hydroxamate ferrichrome siderophore for use as an iron source[1]. FhuA is the E. coli outer membrane transporter of ferrichrome and is the receptor of some phages and colicin M[2]. FhuE is the E. coli receptor of ferric coprogen and ferric-rhodotorulic acid[3]. For more details see FhuD. Disease Haemophilus parasuis uses Fhu to capture iron and is the cause of the Glasser disease in pigs. Structural highlights includes (in cyan) and contains Fe atom. The (Hydrophobic, Polar).[4]

3D structures of Ferric hydroxamate uptake receptor

Updated on 23-June-2024

References

1. ↑ Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD. Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis. Microbiology. 2007 Jul;153(Pt 7):2332-41. PMID:17600077 doi:http://dx.doi.org/10.1099/mic.0.2006/004275-0
2. ↑ Bonhivers M, Plançon L, Ghazi A, Boulanger P, le Maire M, Lambert O, Rigaud JL, Letellier L. FhuA, an Escherichia coli outer membrane protein with a dual function of transporter and channel which mediates the transport of phage DNA. Biochimie. 1998 May-Jun;80(5-6):363-9. PMID:9782377 doi:10.1016/s0300-9084(00)80004-8
3. ↑ Sauer M, Hantke K, Braun V. Ferric-coprogen receptor FhuE of Escherichia coli: processing and sequence common to all TonB-dependent outer membrane receptor proteins. J Bacteriol. 1987 May;169(5):2044-9. PMID:3032906 doi:10.1128/jb.169.5.2044-2049.1987
4. ↑ Locher KP, Rees B, Koebnik R, Mitschler A, Moulinier L, Rosenbusch JP, Moras D. Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell. 1998 Dec 11;95(6):771-8. PMID:9865695