1t2r

From Proteopedia

Revision as of 06:26, 3 May 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1t2r.gif

Template:STRUCTURE 1t2r

Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain


Overview

We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.

About this Structure

1T2R is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196 Page seeded by OCA on Sat May 3 09:26:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t2r"
Personal tools