Function
tRNA methyltransferase (Trm) methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH)[1]. S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction.
For details on Trm to N2 of guanine 6 see TRNA:m2G6 methyltransferase TrmN/Trm14.
- Dual specificity tRNA methyltransferase Rlmn is an E. coli methyltransferase which modifies both ribosomal 23S RNA and tRNA[2].
Structural highlights
Trm is located at the cleft at the subunit interface[3]. Water molecules are shown as red spheres.
3D structures of tRNA methyltransferase
tRNA methyltransferase 3D structures
