1tow

From Proteopedia

Revision as of 07:12, 3 May 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1tow.gif

Template:STRUCTURE 1tow

Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand


Overview

Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.

About this Structure

1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969 Page seeded by OCA on Sat May 3 10:12:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tow"
Personal tools