Semaglutide

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Semaglutide is an analog of the GLP-1 (glucagon-like peptide-1) hormone. It acts as an agonist to the GLP-1 receptor and is used as drug to manage diabetes. Its use has been growing as a weight-loss medication, and potential benefits across a wide range of diseases is currently studied.

Discovery

Semaglutide was discovered in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the GLP-1 hormone, contains two amino acid sequence changes and a covalently attached lipid.

Structure and Receptor Binding

Caption for this structure

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References

Proteopedia Page Contributors and Editors (what is this?)

Karsten Theis, Michal Harel, Jaime Prilusky

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