Structural highlights
Function
WAAF_ECOLI Glycosyltransferase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS) (PubMed:11054112). Catalyzes the addition of the second heptose unit to the heptosyl-Kdo2-lipid A module (PubMed:11054112, PubMed:11717579). The analog ADP-mannose can serve as an alternative donor in place of ADP-L-glycero-D-manno-heptose, but with lower efficiency (PubMed:11054112).[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Gronow S, Brabetz W, Brade H. Comparative functional characterization in vitro of heptosyltransferase I (WaaC) and II (WaaF) from Escherichia coli. Eur J Biochem. 2000 Nov;267(22):6602-11. PMID:11054112 doi:10.1046/j.1432-1327.2000.01754.x
- ↑ Gronow S, Oertelt C, Ervelä E, Zamyatina A, Kosma P, Skurnik M, Holst O. Characterization of the physiological substrate for lipopolysaccharide heptosyltransferases I and II. J Endotoxin Res. 2001;7(4):263-70 PMID:11717579
