7kuy

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Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state

Structural highlights

7kuy is a 5 chain structure with sequence from Aequorea victoria and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.6Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

GLRA2_HUMAN The disease is caused by variants affecting the gene represented in this entry.

Function

GLRA2_HUMAN Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15302677, PubMed:16144831, PubMed:2155780, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).[UniProtKB:Q7TNC8]^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Miller PS, Harvey RJ, Smart TG. Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. Br J Pharmacol. 2004 Sep;143(1):19-26. PMID:15302677 doi:10.1038/sj.bjp.0705875
↑ Miller PS, Da Silva HM, Smart TG. Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J Biol Chem. 2005 Nov 11;280(45):37877-84. PMID:16144831 doi:10.1074/jbc.M508303200
↑ Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Siddique T, Mohandas TK, Becker CM, Betz H. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 1990 Mar;9(3):771-6. PMID:2155780 doi:10.1002/j.1460-2075.1990.tb08172.x
↑ McCracken LM, Trudell JR, McCracken ML, Harris RA. Zinc-dependent modulation of α2 Alcohol Clin Exp Res. 2013 Dec;37(12):2002-10. PMID:23895467 doi:10.1111/acer.12192
↑ Zhang Y, Dixon CL, Keramidas A, Lynch JW. Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations. Neuropharmacology. 2015 Feb;89:391-7. PMID:25445488 doi:10.1016/j.neuropharm.2014.10.026
↑ Yu H, Bai XC, Wang W. Characterization of the subunit composition and structure of adult human glycine receptors. Neuron. 2021 Sep 1;109(17):2707-2716.e6. PMID:34473954 doi:10.1016/j.neuron.2021.08.019