Structural highlights
Function
LYSC_CHICK Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.[1]
Publication Abstract from PubMed
High-resolution crystal structures of lysozyme in the presence of the potential drug V(IV) O(acetylacetonato)(2) under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of V(IV) to V(V) and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V(4) O(12) ](4-) , which interacts with lysozyme non-covalently, and the unprecedented [V(20) O(54) (NO(3) )](n-) , which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules.
Stabilization and Binding of [V(4) O(12) ](4-) and Unprecedented [V(20) O(54) (NO(3) )](n-) to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V(IV) O(acetylacetonato)(2).,Ferraro G, Tito G, Sciortino G, Garribba E, Merlino A Angew Chem Int Ed Engl. 2023 Dec 11;62(50):e202310655. doi: , 10.1002/anie.202310655. Epub 2023 Oct 13. PMID:37768728[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
- ↑ Ferraro G, Tito G, Sciortino G, Garribba E, Merlino A. Stabilization and Binding of [V(4) O(12) ](4-) and Unprecedented [V(20) O(54) (NO(3) )](n-) to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V(IV) O(acetylacetonato)(2). Angew Chem Int Ed Engl. 2023 Dec 11;62(50):e202310655. PMID:37768728 doi:10.1002/anie.202310655
