1gxb
From Proteopedia
|
ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH PYROPHOSPHATE AND MAGNESIUM
Overview
The crystal structure of the dimeric anthranilate, phosphoribosyltransferase (AnPRT) reveals a new category of, phosphoribosyltransferases, designated as class III. The active site of, this enzyme is located within the flexible hinge region of its two-domain, structure. The pyrophosphate moiety of phosphoribosylpyrophosphate is, co-ordinated by a metal ion and is bound by two conserved loop regions, within this hinge region. With the structure of AnPRT available, structural analysis of all enzymatic activities of the tryptophan, biosynthesis pathway is complete, thereby connecting the evolution of its, enzyme members to the general development of metabolic processes. Its, structure reveals it to have the same fold, topology, active site location, and type of association as class II ... [(full description)]
About this Structure
1GXB is a [Single protein] structure of sequence from [Sulfolobus solfataricus] with MG and POP as [ligands]. Active as [[1]], with EC number [2.4.2.18.]. Full crystallographic information is available from [OCA].
Reference
Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry., Mayans O, Ivens A, Nissen LJ, Kirschner K, Wilmanns M, EMBO J. 2002 Jul 1;21(13):3245-54. PMID:12093726
Page seeded by OCA on Mon Oct 29 18:38:13 2007
