| Structural highlights
8fia is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.4Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TENM_DROME Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.[1] [2] [3] [4]
Publication Abstract from PubMed
Teneurins are conserved cell adhesion molecules essential for embryogenesis and neural development in animals. Key to teneurin function is the ability of its extracellular region to form homophilic interactions in cis and/or in trans. However, our molecular understanding of teneurin homophilic interaction remains largely incomplete. Here, we showed that an extracellular fragment of Teneurin-m, the major teneurin homolog in flies, behaves as a homodimer in solution. The structure of Teneurin-m revealed that the transthyretin-related domain from one protomer and the beta-propeller domain from the other mediates Teneurin-m self-association, which is abolished by point mutation of conserved residues. Strikingly, this architecture generates an asymmetric oligomerization interface that enables expansion of Teneurin-m into long zipper arrays reminiscent of protocadherins. An alternatively spliced site that exists only in vertebrates and regulates homophilic interaction in mammalian teneurins overlaps with the fly Teneurin-m self-association interface. Our work provides a molecular understanding of teneurin homophilic interaction and sheds light on its role in teneurin function throughout evolution.
The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers.,Li J, Bandekar SJ, Arac D EMBO Rep. 2023 Jun 5;24(6):e56728. doi: 10.15252/embr.202256728. Epub 2023 May , 11. PMID:37165720[5]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Zheng L, Michelson Y, Freger V, Avraham Z, Venken KJ, Bellen HJ, Justice MJ, Wides R. Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One. 2011;6(8):e22956. PMID:21857973 doi:10.1371/journal.pone.0022956
- ↑ Hong W, Mosca TJ, Luo L. Teneurins instruct synaptic partner matching in an olfactory map. Nature. 2012 Mar 18;484(7393):201-7. PMID:22425994 doi:10.1038/nature10926
- ↑ Mosca TJ, Hong W, Dani VS, Favaloro V, Luo L. Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. Nature. 2012 Mar 18;484(7393):237-41. PMID:22426000 doi:10.1038/nature10923
- ↑ Levine A, Bashan-Ahrend A, Budai-Hadrian O, Gartenberg D, Menasherow S, Wides R. Odd Oz: a novel Drosophila pair rule gene. Cell. 1994 May 20;77(4):587-98. PMID:7514504 doi:10.1016/0092-8674(94)90220-8
- ↑ Li J, Bandekar SJ, Araç D. The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers. EMBO Rep. 2023 Jun 5;24(6):e56728. PMID:37165720 doi:10.15252/embr.202256728
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