Peptide Transporter Function & Structure
Human promiscuous peptide transporter 1 (PepT1) plays a crucual role in nutrition, transporting di- and tri-peptides from digested protein into intestinal cells.[1] It is also crucial in uptake of orally delivered drugs.[1] PepT1 is a 708-amino acid protein with an extracellular domain (beta sheets), a transmembrane transporter domain (alpha helices) with a cytoplasmic amphipathic 2-helix linker (green protrusion). The latter looks like the toe of a boot formed by the linker (toe) with the transmembrane domain. The function of the cytoplasmic and linker domains are not well understood, although the cytoplasmic domain appears to be important in transport[2].
outward facing morph spacefilled showing dipeptide visible/hidden
