Structure
Bound to the GLP-1 receptor, GLP-1 has an that is near glycine in some complexes. In solution, GLP-1 is predicted to be alpha-helical in its center.
Synthesis
GLP-1 is made as part of and processed distinctly depending on cell-type.
Degradation
GLP-1 is initially degraded by dipeptidyl peptidase IV.
Binding to receptor
GLP-1 binds to the extracellular side of the GPL-1 receptor, a G-protein coupled receptor. When , GLP-1 acts as agonist resulting in cAMP production in the cell.
Consequences of receptor binding