8raq

Structural highlights

Function

MMAA1_MYCTU Involved in the conversion of a cis-olefin into a trans-olefin with concomitant introduction of an allylic methyl branch at the proximal position of the precursor to both the methoxy and ketomycolic acids. It directly affects the cis- to trans ratio and indirectly affects the keto to methoxy ratio.^{[1] [2]}

References

1. ↑ Barkan D, Rao V, Sukenick GD, Glickman MS. Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates. J Bacteriol. 2010 Jul;192(14):3661-8. doi: 10.1128/JB.00312-10. Epub 2010 May 14. PMID:20472794 doi:http://dx.doi.org/10.1128/JB.00312-10
2. ↑ Yuan Y, Crane DC, Musser JM, Sreevatsan S, Barry CE 3rd. MMAS-1, the branch point between cis oxygenated mycolates in Mycobacterium tuberculosis. J Biol Chem. 1997 Apr 11;272(15):10041-9. PMID:9092547 doi:10.1074/jbc.272.15.10041