| Structural highlights
Function
VKT2I_RADCR Serine protease inhibitor that also shows protective effect in a cytotoxicity model (PubMed:32144281). It binds to all proteases tested (trypsin (Ki=52 nM), alpha-chymotrypsin, cathepsin G, kallikrein, and human neutrophil elastase) (PubMed:32144281). It significantly increases neuroblastoma cell viability in an in vitro neurotoxicity model, being a consequence of an effective decrease of reactive oxygen species (ROS) level in the cells (PubMed:32144281, PubMed:35563513). It also seems to protect cells by inhibiting ATP-induced purinoceptor (P2RX7) activation (PubMed:35563513).[1] [2]
References
- ↑ Kvetkina A, Leychenko E, Chausova V, Zelepuga E, Chernysheva N, Guzev K, Pislyagin E, Yurchenko E, Menchinskaya E, Aminin D, Kaluzhskiy L, Ivanov A, Peigneur S, Tytgat J, Kozlovskaya E, Isaeva M. A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine. Sci Rep. 2020 Mar 6;10(1):4205. PMID:32144281 doi:10.1038/s41598-020-61034-x
- ↑ Kvetkina A, Pislyagin E, Menchinskaya E, Yurchenko E, Kalina R, Kozlovskiy S, Kaluzhskiy L, Menshov A, Kim N, Peigneur S, Tytgat J, Ivanov A, Ayvazyan N, Leychenko E, Aminin D. Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation. Int J Mol Sci. 2022 May 4;23(9):5115. PMID:35563513 doi:10.3390/ijms23095115
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