1gxd
From Proteopedia
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PROMMP-2/TIMP-2 COMPLEX
Overview
Matrix metalloproteinases (MMPs) are a family of multidomain enzymes, involved in the physiological degradation of connective tissue, as well as, in pathological states such as tumor invasion and arthritis. Apart from, transcriptional regulation, MMPs are controlled by proenzyme activation, and a class of specific tissue inhibitors of metalloproteinases (TIMPs), that bind to the catalytic site. TIMP-2 is a potent inhibitor of MMPs, but, it has also been implicated in a unique cell surface activation mechanism, of latent MMP-2/gelatinase A/type IV collagenase (proMMP-2), through its, binding to the hemopexin domain of proMMP-2 on the one hand and to a, membrane-type MMP activator on the other. The present crystal structure of, the human proMMP-2/TIMP-2 complex reveals an interaction ... [(full description)]
About this Structure
1GXD is a [Protein complex] structure of sequences from [Homo sapiens] with SO4, ZN and CA as [ligands]. Active as [[1]], with EC number [3.4.24.24]. Full crystallographic information is available from [OCA].
Reference
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2., Morgunova E, Tuuttila A, Bergmann U, Tryggvason K, Proc Natl Acad Sci U S A. 2002 May 28;99(11):7414-9. PMID:12032297
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