9cbn

Structural highlights

Function

CAPSD_HASV1 The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the immature VP70 virion.[UniProtKB:Q9IFX1] The immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry (By similarity). During maturation, VP70 undergoes a loss of 60 peripentonal spikes, which likely plays an important role in viral infectivity (By similarity).[UniProtKB:Q9IFX1] Self-assembles to form an icosahedral capsid with a T=3 symmetry, about 43 nm in diameter (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707).^[1] VP25 and VP27 Forms the spikes at the surface of the virion (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). Plays a role in the attachment to target host cell (Probable). This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).[UniProtKB:Q9IFX1]^[2] VP25 and VP27 Forms the spikes at the surface of the virion (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). Plays a role in the attachment to target host cell (PubMed:33396308). This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).[UniProtKB:Q9IFX1]^{[3] [4]}

References

1. ↑ York RL, Yousefi PA, Bogdanoff W, Haile S, Tripathi S, DuBois RM. Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid. J Virol. 2015 Dec 9. pii: JVI.02666-15. PMID:26656707 doi:http://dx.doi.org/10.1128/JVI.02666-15
2. ↑ York RL, Yousefi PA, Bogdanoff W, Haile S, Tripathi S, DuBois RM. Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid. J Virol. 2015 Dec 9. pii: JVI.02666-15. PMID:26656707 doi:http://dx.doi.org/10.1128/JVI.02666-15
3. ↑ York RL, Yousefi PA, Bogdanoff W, Haile S, Tripathi S, DuBois RM. Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid. J Virol. 2015 Dec 9. pii: JVI.02666-15. PMID:26656707 doi:http://dx.doi.org/10.1128/JVI.02666-15
4. ↑ Aguilar-Hernández N, Meyer L, López S, DuBois RM, Arias CF. Protein Disulfide Isomerase A4 Is Involved in Genome Uncoating during Human Astrovirus Cell Entry. Viruses. 2020 Dec 31;13(1):53. PMID:33396308 doi:10.3390/v13010053