Structural highlights
Function
CXCL3_HUMAN Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.[1]
References
- ↑ Wuyts A, Govaerts C, Struyf S, Lenaerts JP, Put W, Conings R, Proost P, Van Damme J. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. Eur J Biochem. 1999 Mar;260(2):421-9. PMID:10095777
