Structural highlights
Function
PIL1_ECOLI Propilin is the precursor of the pilus subunit, pilin, that forms conjugative pili, the filamentous surface appendages required for cell-to-cell contact during the earlier stages of bacterial conjugation, and that retract after contact is established. Mature pilin is assembled with the help of TraQ and TraX (PubMed:1464628, PubMed:6090426). Functions as a receptor for CdiA-CT from E.cloacae and E.coli, although it is not clear if this is physiologically relevant (PubMed:24889811).[1] [2] [3]
References
- ↑ Paiva WD, Grossman T, Silverman PM. Characterization of F-pilin as an inner membrane component of Escherichia coli K12. J Biol Chem. 1992 Dec 25;267(36):26191-7 PMID:1464628
- ↑ Beck CM, Diner EJ, Kim JJ, Low DA, Hayes CS. The F pilus mediates a novel pathway of CDI toxin import. Mol Microbiol. 2014 Jul;93(2):276-90. doi: 10.1111/mmi.12658. Epub 2014 Jun 15. PMID:24889811 doi:http://dx.doi.org/10.1111/mmi.12658
- ↑ Frost LS, Paranchych W, Willetts NS. DNA sequence of the F traALE region that includes the gene for F pilin. J Bacteriol. 1984 Oct;160(1):395-401. PMID:6090426 doi:10.1128/jb.160.1.395-401.1984
