Structural highlights
Disease
CCG2_MOUSE Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.
Function
CCG2_MOUSE Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Publication Abstract from PubMed
Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. We used cryo-electron microscopy (cryo-EM) to reconstruct the 36 kDa TARP subunit gamma2 to 2.3 A and reveal the structural diversity of TARPs. Our data reveals critical motifs that distinguish TARPs from claudins and define how sequence variations within TARPs differentiate subfamilies and their regulation of AMPARs.
Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit gamma2.,Hale WD, Romero AM, Huganir RL, Twomey EC bioRxiv [Preprint]. 2023 Nov 28:2023.11.28.569079. doi: , 10.1101/2023.11.28.569079. PMID:38076787[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hale WD, Romero AM, Huganir RL, Twomey EC. Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit γ2. bioRxiv [Preprint]. 2023 Nov 28:2023.11.28.569079. PMID:38076787 doi:10.1101/2023.11.28.569079
