9knu

Structural highlights

Function

PORTL_BPMU Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine. Acts as a linker between the capsid and tail. Required for attachment of the neck proteins to the capsid.^{[1] [2] [3]}

References

1. ↑ Morgan GJ, Hatfull GF, Casjens S, Hendrix RW. Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus. J Mol Biol. 2002 Mar 29;317(3):337-59. PMID:11922669 doi:10.1006/jmbi.2002.5437
2. ↑ Grimaud R. Bacteriophage Mu head assembly. Virology. 1996 Mar 1;217(1):200-10. PMID:8599204 doi:10.1006/viro.1996.0107
3. ↑ Grimaud R, Toussaint A. Assembly of both the head and tail of bacteriophage Mu is blocked in Escherichia coli groEL and groES mutants. J Bacteriol. 1998 Mar;180(5):1148-53. PMID:9495752 doi:10.1128/JB.180.5.1148-1153.1998