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1yrk
From Proteopedia
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The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain
Overview
In this issue of Cell, report that the C2 domain of the serine/threonine, protein kinase Cdelta is a phosphotyrosine binding domain and present the, crystal structure of this C2 domain bound to a peptide containing, phosphotyrosine. Prior to this work, C2 domains were thought to bind only, to phospholipids or to unphosphorylated proteins, and the SH2 and PTB, domains were the only signaling domains known to recognize, phosphotyrosine. This new role for the C2 domain links phosphotyrosine, recognition directly to serine/threonine kinase activity and reveals an, unexpected mechanism for crosstalk between distinct signaling pathways.
About this Structure
1YRK is a Single protein structure of sequence from Homo sapiens with ACY as ligand. Full crystallographic information is available from OCA.
Reference
C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022
Page seeded by OCA on Mon Nov 12 20:23:42 2007
Categories: Homo sapiens | Single protein | Benes, C.H. | Cantley, L.C. | Dharia, T. | Elia, A.E. | Soltoff, S.P. | Wu, N. | ACY | C2 domain
