| Structural highlights
Function
AGDP1_ARATH Heterochromatin-binding protein that preferentially occupies long transposons and specifically recognizes the histone H3 'Lys-9' methylation (H3K9me) marks, with a stronger affinity for dimethylated H3K9 (H3K9me2) (PubMed:30382101, PubMed:30425322). Required for transcriptional silencing, non-CG DNA methylation (e.g. CHG and CHH regions), and H3K9 dimethylation (H3K9me2) at some loci (PubMed:30382101, PubMed:30425322). Mediates heterochromatin phase separation and chromocenter formation (PubMed:30425322).[1] [2]
References
- ↑ Zhang C, Du X, Tang K, Yang Z, Pan L, Zhu P, Luo J, Jiang Y, Zhang H, Wan H, Wang X, Wu F, Tao WA, He XJ, Zhang H, Bressan RA, Du J, Zhu JK. Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin. Nat Commun. 2018 Oct 31;9(1):4547. doi: 10.1038/s41467-018-06965-w. PMID:30382101 doi:http://dx.doi.org/10.1038/s41467-018-06965-w
- ↑ Zhao S, Cheng L, Gao Y, Zhang B, Zheng X, Wang L, Li P, Sun Q, Li H. Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Res. 2019 Jan;29(1):54-66. PMID:30425322 doi:10.1038/s41422-018-0104-9
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