Structural highlights
Function
SNPC1_HUMAN Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.[1]
References
- ↑ Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. J Biol Chem. 2003 May 16;278(20):18649-57. Epub 2003 Mar 5. PMID:12621023 doi:http://dx.doi.org/10.1074/jbc.M204247200
