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Structural highlights

Function

MPS1_PYROR Mitogen-activated protein kinase; part of the MCK1-MKK2-MPS1 MAP kinase (MAPK) signal transduction cascade that is essential for cell wall integrity and plant infection, but not for plant defense responses (PubMed:18344407, PubMed:22321443, PubMed:28424497, PubMed:28799700, PubMed:9770551). Beside its role in pathogenesis, the MPS1 cascade is active in conidiation and cellular stress responses (PubMed:9770551). Targets downstream of the MPS1-MAPK pathway include transcription factors MIG1 and SWI6, as well as GSK1 and MPG1 (PubMed:18344407, PubMed:22321443, PubMed:28424497).^{[1] [2] [3] [4] [5]}

References

1. ↑ Mehrabi R, Ding S, Xu JR. MADS-box transcription factor mig1 is required for infectious growth in Magnaporthe grisea. Eukaryot Cell. 2008 May;7(5):791-9. PMID:18344407 doi:10.1128/EC.00009-08
2. ↑ Qi Z, Wang Q, Dou X, Wang W, Zhao Q, Lv R, Zhang H, Zheng X, Wang P, Zhang Z. MoSwi6, an APSES family transcription factor, interacts with MoMps1 and is required for hyphal and conidial morphogenesis, appressorial function and pathogenicity of Magnaporthe oryzae. Mol Plant Pathol. 2012 Sep;13(7):677-89. PMID:22321443 doi:10.1111/j.1364-3703.2011.00779.x
3. ↑ Zhou T, Dagdas YF, Zhu X, Zheng S, Chen L, Cartwright Z, Talbot NJ, Wang Z. The glycogen synthase kinase MoGsk1, regulated by Mps1 MAP kinase, is required for fungal development and pathogenicity in Magnaporthe oryzae. Sci Rep. 2017 Apr 19;7(1):945. PMID:28424497 doi:10.1038/s41598-017-01006-w
4. ↑ Zhang X, Liu W, Li Y, Li G, Xu JR. Expression of HopAI interferes with MAP kinase signalling in Magnaporthe oryzae. Environ Microbiol. 2017 Oct;19(10):4190-4204. PMID:28799700 doi:10.1111/1462-2920.13884
5. ↑ Xu JR, Staiger CJ, Hamer JE. Inactivation of the mitogen-activated protein kinase Mps1 from the rice blast fungus prevents penetration of host cells but allows activation of plant defense responses. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12713-8. PMID:9770551 doi:10.1073/pnas.95.21.12713
6. ↑ Kong Z, Li S, Li J, Chen Y, Chen M, Zhang X, Wang D, Liu J. Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi. J Agric Food Chem. 2024 Dec 11;72(49):27115-27124. PMID:39622772 doi:10.1021/acs.jafc.4c09504