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Structural highlights
This structure models the region of PPARδ from Gln171 to Tyr441[3]. It is composed of , with one small . The structure is bound to a synthetic ligand, , which contains a carboxylate group, a thiophenol, a thiazole, and a fluorine substituted phenyl ring. This ligand can be divided into a hydrophilic head group (carboxylate) and a hydrophobic tail (thiophenol, thiazole, phenyl). There is also a glycerol molecule in the structure, which is an artifact of the crystallization process and is not biologically relevant.
The ligand binding pocket (LBP) is made of (arm I residues are green, arm II residues are blue, arm III residues are red).
[4]
Function
Disease
Relevance
