8zar

Structural highlights

Function

EMRA_ECOLI Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC.^{[1] [2]}

References

1. ↑ Borges-Walmsley MI, Beauchamp J, Kelly SM, Jumel K, Candlish D, Harding SE, Price NC, Walmsley AR. Identification of oligomerization and drug-binding domains of the membrane fusion protein EmrA. J Biol Chem. 2003 Apr 11;278(15):12903-12. PMID:12482849 doi:10.1074/jbc.M209457200
2. ↑ Lomovskaya O, Lewis K. Emr, an Escherichia coli locus for multidrug resistance. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8938-42. PMID:1409590 doi:10.1073/pnas.89.19.8938