Structural highlights
Function
NOL9_HUMAN Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032).[1] [2]
References
- ↑ Heindl K, Martinez J. Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing. EMBO J. 2010 Dec 15;29(24):4161-71. PMID:21063389 doi:10.1038/emboj.2010.275
- ↑ Gordon J, Pillon MC, Stanley RE. Nol9 Is a Spatial Regulator for the Human ITS2 Pre-rRNA Endonuclease-Kinase Complex. J Mol Biol. 2019 Sep 6;431(19):3771-3786. PMID:31288032 doi:10.1016/j.jmb.2019.07.007
